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Nuclease resistance of REP 9, REP 9C and their non-phosphorothioated analogs
| Nuclease resistance (- = fully degraded, ++++ = fully resistant) | ||||||
|---|---|---|---|---|---|---|
| compound | sequence | chemistry | Phosphodiesterase II | S1 Nuclease | Bal 31 | Exo I |
| REP 2015 | N40 (degenerate) | PO | - | - | - | - |
| REP 9 | PS | ++ | - | ++++ | ++++ | |
| REP 2110 | C40 | PO | ++++ | ++ | - | - |
| REP 9C | PS | ++++ | ++ | ++++ | ++++ | |
PO = phosphodiester, PS = phosphorothioate
