Table 1.
Clinical Laboratory findings
| Haematology and biochemistry tests | Reference range | Screening | Admission | Adm +1 | Adm +2 | Adm +3 | Adm +4 = Discharge |
|---|---|---|---|---|---|---|---|
| Haemoglobin (mmol/l) | 7.3 - 9.7 | 7.1 | 6.9 | 7.1 | 6.9 | ||
| Leukocytes (*109/l) | 3.5 - 11.0 | 6.6 | 7.9 | 3.9 | 5.4 | ||
| Platelets (*109/l) | 120 - 350 | 259 | 160 | 254 | 302 | ||
| Glucose (mmol/l) | 4.0 - 5.5 (fasting) | 4.6 | 4.9 | ||||
| Sodium (mmol/l) | 137 - 144 | 142 | 140 | 137 | |||
| Potassium (mmol/l) | 3.4 - 4.6 | 4.1 | 3.9 | 3.9 | |||
| Creatinin (umol/l) | 45 - 90 | 61 | 55 | 60 | |||
| Urea nitrogen (mmol/l) | 3.0 - 7.0 | 4.9 | 3.2 | ||||
| Bilirubin (umol/l) | ≤ 17 | <10 | <10 | ||||
| Alkaline phosphatase (U/l) | ≤ 120 | 55 | 74 | 66 | 69 | 69 | |
| Aspartate aminotransferase (U/l) | ≤ 40 | 16 | 132 | 104 | 111 | 89 | 83 |
| Alanine aminotransferase (U/l) | ≤ 45 | 15 | 137 | 134 | 171 | 166 | 164 |
| Lactate dehydrogenase (U/l) | ≤ 450 | 313 | 540 | 534 | 562 | 384 | |
| gamma GT (U/l) | ≤ 35 | 13 | 29 | 39 | 36 | 35 | |
| Creatinin Kinase (U/l) | ≤ 170 | 296 | 105 | 28 | |||
| Troponin I (ug/l) | ≤ 0.20 | 10.40 | 2.75 | 0.20 | |||
| CRP (mg/l) | ≤ 10 | 26 | |||||
| Cholesterol (mmol/l) | 4.7 - 6.5 | 4.0 | |||||
| Triglycerides (mmol/l) | 0.8 - 2.0 | 1.5 | |||||
| HDL cholesterol (mmol/l) | 1.10 - 1.70 | 1.20 | |||||
| LDL cholesterol (mmol/l) | ≤ 3.5 | 2.12 | |||||
| Coagulation assays | |||||||
| INR | 0.9-1.1 | 1.0 | 1.0 | ||||
| Fibrinogen (mg/l) | 2000-4000 | 4320 | |||||
| Factor VIII activity (%) | 60-150 | 130% | |||||
| Protein C activity (%) | 70-150 | >100% | |||||
| Free protein S antigen (%) | 55-115 | 92% | |||||
| Homocystein (μmol/l) | < 13.4 | 9.3 | |||||
| Antithrombin III (%) | 85-120 | 98% | |||||
| Factor II mutation | negative | negative | |||||
| Factor V (Leiden) mutation | negative | negative | |||||
| von Willebrand Factor (%) | 50-150 | 166% | |||||
| ADAMTS13 activity (%) | 60-140 | 90% | |||||
| Additional tests | |||||||
| Convalescent microbiological tests | adenovirus, RS-virus, influenza virus, mycoplasma pneumonia, Chlamydia, Q-fever, para-influenza, enterovirus | Negative | |||||
| Auto-immune antibodies | ANCA, anticardiolipin antibodies, β2 glycoprotein, lupus anticoagulans, anti-heart (rat) antibodies | Negative | |||||
| Toxicology test | tetrahydrocannabinol, amphetamine-derivatives, cocaine, diazepam, methadone, tramadol, opiates | Negative | |||||
| Inflammatory parameters | Interleukin 6, Interleukin 8 | < detection limit | |||||
| Time after last dose | 7 h15 | 103 h45 | |||||
| Artemether | < detection limit | < detection limit | |||||
| Dihydroartemisinin | 26.5 ng/ml | < detection limit | |||||
| Lumefantrine | 4308 ng/ml and | 443 ng/ml | |||||
| Desbutyl-lumefantrine | 40 ng/ml | 18 ng/ml | |||||