Table 3.
Odds ratios (ORs) and 95% confidence intervals (CIs) for increasing severity of self-reported Raynaud-like phenomena and paresthesias in hands and feet from proportional odds ordinal logistic regression models*
| Variable | Raynaud-like phenomena |
Paresthesias |
||||||
| Hands |
Feet |
Hands |
Feet |
|||||
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| Age at follow-up† | 1.2 (1.1 to 1.4) | .002 | 1.3 (1.1 to 1.4) | <.001 | 1.2 (1.1 to 1.4) | .001 | 1.4 (1.2 to 1.6) | <.001 |
| Length of follow-up‡ | 1.01 (0.98 to 1.04) | .68 | 1.0 (0.97 to 1.03) | .90 | 1.01 (0.98 to 1.04) | .47 | 1.01 (0.98 to 1.04) | .73 |
| Chemotherapy | <.001 | <.001 | <.001 | <.001 | ||||
| No | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | ||||
| 1–4 cycles | 2.9 (2.2 to 3.9) | <.001 | 2.4 (1.8 to 3.3) | <.001 | 2.0 (1.5 to 2.7) | <.001 | 2.2 (1.7 to 3.0) | <.001 |
| ≥5 cycles | 8.0 (4.4 to 14.7) | <.001 | 6.3 (3.4 to 11.8) | <.001 | 3.9 (2.1 to 7.3) | <.001 | 3.1 (1.7 to 5.7) | <.001 |
| Dose intensive | 5.7 (3.2 to 9.9) | <.001 | 4.7 (2.6 to 8.3) | <.001 | 2.3 (1.3 to 4.1) | .007 | 3.8 (2.1 to 6.9) | <.001 |
| Radiotherapy | .10 | .10 | .22 | .04 | ||||
| No | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | ||||
| Yes | 1.3 (0.95 to 1.9) | 1.4 (0.95 to 1.9) | 1.3 (0.9 to 1.8) | 1.5 (1.01 to 2.1) | ||||
| RPLND | .20 | .52 | .15 | .27 | ||||
| No | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | ||||
| Yes | 1.3 (0.9 to 1.8) | 1.1 (0.8 to 1.6) | 1.3 (.9 to 1.9) | 1.2 (0.9 to 1.7) | ||||
| Cigarette smoking | <.001 | <.001 | <.001 | <.001 | ||||
| Never daily | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | ||||
| Former daily | 1.1 (0.8 to 1.5) | .57 | 0.9 (0.7 to 1.3) | .71 | 1.1 (0.8 to 1.6) | .44 | 1.8 (1.4 to 2.5) | <.001 |
| Current daily | 1.7 (1.3 to 2.2) | <.001 | 1.5 (1.2 to 2.0) | .002 | 1.9 (1.4 to 2.5) | <.001 | 2.2 (1.6 to 2.8) | <.001 |
| Educational level | .03 | .01 | <.001 | .004 | ||||
| Primary, middle, or high school | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | ||||
| College or university | 0.8 (0.6 to 0.98) | 0.7 (0.6 to 0.9) | 0.6 (0.4 to 0.7) | 0.7 (0.6 to 0.9) | ||||
| Marital status | .04 | .003 | .81 | .31 | ||||
| Unmarried or living alone | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | ||||
| Married or cohabitating | 0.8 (0.6 to 0.98) | 0.7 (0.5 to 0.9) | 1.0 (.7 to 1.3) | 0.9 (0.7 to 1.4) | ||||
*
RPLND = retroperitoneal lymph node dissection.
†
Per 10-year increase.
‡
Per 1-year increase.