Table 3.
Association of PLIN polymorphisms with metabolic traits in normoglycemic non-Hispanic white women without PCOS
| rs4578621 |
rs2289487 |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CC | CG | GG | P* | Padj† | AA | AG | GG | P* | Padj† | ||
| N | 63 | 14 | 0 | N | 36 | 33 | 8 | ||||
| Age (yr) | 31.8 ± 10.7 | 34.6 ± 11.7 | 0.374 | Age (yr) | 33.1 ± 11.6 | 32.2 ± 10.6 | 28.8 ± 8.9 | 0.363 | |||
| BMI (kg/m2) | 26.9 ± 7.2 | 26.4 ± 5.3 | 0.771 | BMI (kg/m2) | 26 ± 5.7 | 26.8 ± 6.3 | 30.8 ± 11.8 | 0.117 | |||
| Total cholesterol (mg/dL) | 165.8 ± 31 | 172.6 ± 14.2 | 0.480 | 0.555 | Total cholesterol (mg/dL) | 159.7 ± 23.7 | 174 ± 31.8 | 162.4 ± 26.2 | 0.262 | 0.276 | |
| Triglycerides (mg/dL) | 70.4 (58.6-84.7) | 60.3 (44.8-81.1) | 0.440 | 0.550 | Triglycerides (mg/dL) | 64.5 (48.7- 85.3) |
77 (63.3-93.7) | 45.6 (22-94.5) | 0.832 | 0.543 | |
| HDL (mg/dL) | 54.4 ± 12.4 | 53.5 ± 10.4 | 0.836 | 0.574 | HDL (mg/dL) | 56.6 ± 12.5 | 52.9 ± 11.4 | 50.6 ± 12.5 | 0.186 | 0.383 | |
| LDL (mg/dL) | 94.3 ± 26.7 | 106 ± 17.7 | 0.173 | 0.178 | LDL (mg/dL) | 86.9 ± 20.3 | 103.7 ± 27.6 | 101.2 ± 26 | 0.036 | 0.046 | |
| Glycohemoglobin (%) | 5.3 (5.2-5.4) | 5.3 (5.1-5.4) | 0.883 | 0.757 | Glycohemoglobin (%) | 5.3 (5.1-5.4) | 5.3 (5.2-5.4) | 5.4 (5.1-5.7) | 0.263 | 0.317 | |
| Fasting glucose (mmol/l) | 4.9 (4.9-5) | 5 (4.7-5.3) | 0.678 | 0.763 | Fasting glucose (mmol/l) | 4.9 (4.8-4.9) | 5 (4.9-5.2) | 5 (4.7-5.4) | 0.045 | 0.039 | |
| 2-h glucose (mmol/l) | 6.5 (6.3-6.7) | 6.5 (6.2-6.8) | 0.904 | 0.920 | 2-h glucose (mmol/l) | 6.5 (6.2-6.8) | 6.5 (6.3-6.8) | 6.8 (6.2-7.4) | 0.511 | 0.438 | |
| Fasting insulin(pmol/l) | 29.7 (24.6-35.9) | 32.2 (22.5-46) | 0.712 | 0.263 | Fasting insulin(pmol/l) | 26.9 (21.5- 33.8) |
30.8 (24-39.6) | 46.3 (21.5- 99.4) |
0.071 | 0.537 | |
| 2-h insulin (pmol/l) | 195.2 (169.5- 224.9) |
207.9 (154.2- 280.4) |
0.699 | 0.343 | 2-h insulin (pmol/l) | 189.1 (160.4- 222.9) |
200.3 (162.1- 247.4) |
227.5 (129.1- 401) |
0.398 | 0.923 | |
| HOMA-IR | 1.1 (0.9-1.3) | 1.2 (0.8-1.7) | 0.693 | 0.271 | HOMA-IR | 1 (0.8-1.2) | 1.1 (0.9-1.5) | 1.7 (0.8-3.9) | 0.053 | 0.418 | |
| rs2304795 |
rs1052700 |
||||||||||
| TT | TC | CC | P * | Padj † | TT | TA | AA | P * | Padj † | ||
| N | 40 | 28 | 9 | N | 36 | 34 | 7 | ||||
| Age (yr) | 32.6 ± 10.9 | 31.4 ± 10.8 | 33.8 ± 12.4 | 0.978 | Age (yr) | 31.4 ± 10.8 | 33.7 ± 11.2 | 29.6 ± 10.8 | 0.856 | ||
| BMI (kg/m2) | 27.1 ± 6.6 | 27.4 ± 7.9 | 24 ± 3.3 | 0.399 | BMI (kg/m2) | 25.6 ± 6 | 28.2 ± 7.9 | 26.7 ± 4.5 | 0.260 | ||
| Total cholesterol (mg/dL) | 170.6 ± 31.3 | 164.6 ± 25 | 159.3 ± 28.6 | 0.291 | 0.315 | Total cholesterol (mg/dL) | 159.3 ± 24.8 | 171.3 ± 31.6 | 185.3 ± 15.9 | 0.042 | 0.073 |
| Triglycerides (mg/dL) | 79.9 (63.6- 100.2) |
57.8 (44.5-75.1) | 58.2 (36.9- 91.9) |
0.066 | 0.119 | Triglycerides (mg/dL) | 67.2 (54.5-83) | 69.1 (52.9- 90.3) |
70.2 (46.3- 106.4) |
0.851 | 0.998 |
| HDL (mg/dL) | 55.1 ± 12.7 | 52.9 ± 12.2 | 54.7 ± 8.4 | 0.732 | 0.436 | HDL (mg/dL) | 56.5 ± 13.3 | 52.4 ± 10.4 | 53.3 ± 13.9 | 0.279 | 0.326 |
| LDL (mg/dL) | 96.4 ± 25.6 | 98.2 ± 28.1 | 91.9 ± 19.6 | 0.835 | 0.955 | LDL (mg/dL) | 87.4 ± 21.7 | 101.4 ± 27.2 | 117.8 ± 14.2 | 0.007 | 0.014 |
| Glycohemoglobin (%) | 5.3 (5.2-5.4) | 5.3 (5.2-5.4) | 5.3 (5.1-5.5) | 0.976 | 0.768 | Glycohemoglobin (%) | 5.3 (5.2-5.4) | 5.3 (5.2-5.4) | 5.3 (5-5.5) | 0.919 | 0.765 |
| Fasting glucose (mmol/l) | 4.9 (4.8-5) | 5 (4.8-5.2) | 5.1 (4.8-5.4) | 0.112 | 0.059 | Fasting glucose (mmol/l) | 4.9 (4.8-5) | 5.1 (4.9-5.2) | 4.9 (4.6-5.2) | 0.147 | 0.248 |
| 2-h glucose (mmol/l) | 6.4 (6.1-6.6) | 6.8 (6.5-7) | 6.5 (5.9-7.2) | 0.150 | 0.162 | 2-h glucose (mmol/l) | 6.4 (6.2-6.6) | 6.7 (6.3-7) | 6.6 (6.2-7) | 0.279 | 0.224 |
| Fasting insulin(pmol/l) | 27.8 (22.7-34.1) | 37.3 (27-51.7) | 21.4 (15.3- 29.9) |
0.906 | 0.454 | Fasting insulin(pmol/l) | 26.3 (21.1- 32.7) |
34.1 (25.6- 45.5) |
34.1 (21.3- 54.5) |
0.152 | 0.335 |
| 2-h insulin (pmol/l) | 188.1 (159.9- 221.2) |
232 (185.8- 289.7) |
143.6 (93.3- 220.9) |
0.853 | 0.874 | 2-h insulin (pmol/l) | 181.3 (154.8- 212.3) |
213.8 (172.4- 265.1) |
211.3 (116.4- 383.7) |
0.252 | 0.366 |
| HOMA-IR | 1 (0.8-1.2) | 1.4 (1-1.9) | 0.8 (0.6-1.2) | 0.791 | 0.359 | HOMA-IR | 0.9 (0.8-1.2) | 1.3 (0.9-1.7) | 1.2 (0.8-2) | 0.129 | 0.295 |
Mean ± SD or geometric mean (95% CI) are shown.
*
Not adjusted for age and BMI.
†
Adjusted for age and BMI.