FIG. 6.

Expression of differentiation marker mRNAs in (A–C) wild-type (+/+) and Pparβ/δ-null (−/−) mouse skin or (D–F) 308 neoplastic keratinocyte cell line. Total RNA was isolated from mouse skin or cells following treatment with either GW0742, nimesulide, or GW0742 and nimesulide as described in “Materials and Methods” section. mRNA encoding Adrp (A and D), K1 (B and E), or K10 (C and F) was quantified using qPCR. Values represent the mean ± SEM. Values with different letters are significantly different, p ≤ 0.05.