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. 2008 Oct 16;66(3):407. doi: 10.1007/s00018-008-8303-z

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© Birkhäuser Verlag, Basel 2008

Open Access This is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License ( https://creativecommons.org/licenses/by-nc/2.0 ), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Effector proteins form an aromatic cage that recognizes methylated lysine residues (A–E). Cartoon representations corresponding to the three dimensional structure of effector protein methyl-lysine binding domains (top half of each section) with a close up view of the aromatic cage in association with a methylated ligand (bottom half of each section). (A) The KMT1D ankyrin repeat in complex with H3K9me2 (PDB 3b95), repeats 3, 4 and 5 shown only. (B) The chromodomain of heterochromatin protein 1 (HP1) in complex with H3K9me2 (PDB 1kna). (C) The MBT repeats of L3MBTL1 in complex with H4K20me2 (PDB 2pqw), repeat 2 shown only. (D) The PHD finger of bromodomain PHD transcription factor (BPTF) in complex with H3K4me3 (PDB 2f6j), PHD finger shown only. (E) The double tudor domain of KDM4A in complex with H4K20me3 (PDB 2qqs).