Table 1.

Distribution of APOE and ACE genotypes and allele frequencies for cases and controls (both non-demented and HF non-demented), relative to years 2, 6 and 10 (corresponding to waves 2, 3 and 5, respectively)

	2 years/wave 2						6 years/wave 3						10 years/wave 5
	Incident demented		Non-demented		HF non-demented		Incident demented		Non-demented		HF non-demented		Incident demented		Non-demented		HF non-demented
	n	%	n	%	n	%	n	%	n	%	n	%	n	%	n	%	n	%
APOE
Allele
ε2	4	10	166	9	70	9	5	3	161	9	70	9	8	7	77	10	34	9
ε3	28	70	1,471	79	639	78	114	78	1,357	79	595	77	77	71	616	79	290	80
ε4	8	20	233	12	109	13	27	18	206	12	103	13	23	21	83	11	40	11
Total	40		1,870		818		146		1,724		768		108		776		364
Genotype
ε2/ε2	0	0	7	1	3	1	1	1	6	1	4	1	0	0	3	1	2	1
ε2/ε3	3	15	128	14	55	13	2	3	126	15	55	14	7	13	62	16	27	15
ε2/ε4	1	5	24	3	9	2	1	1	23	3	7	2	1	2	9	2	3	2
ε3/ε3	11	55	583	62	251	61	46	63	537	62	229	60	26	48	244	63	114	63
ε3/ε4	3	15	177	19	82	20	20	27	157	18	82	21	18	33	66	17	35	19
ε4/ε4	2	10	16	2	9	2	3	4	13	2	7	2	2	4	4	1	1	1
Total	20		935		409		73		862		384		54		388		182
ACE
Allele
I	20	50	838	50	365	49	64	53	773	50	341	48	51	53	349	50	165	48
D	20	50	834	50	385	51	56	47	779	50	363	52	45	47	349	50	177	52
Total	40		1,672		750		120		1,552		704		96		698		342
Genotype
D/D	7	35	227	27	107	29	15	25	213	27	104	30	11	23	98	28	49	29
I/D	6	30	380	45	171	46	26	43	353	45	155	44	23	48	153	44	79	46
I/I	7	35	229	27	97	26	19	32	210	27	93	26	14	29	98	28	43	25
Total	20		836		375		60		776		352		48		349		171