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. 2010 Jan 8;6(1):e1000803. doi: 10.1371/journal.pgen.1000803

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Han et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Quadrivalents at meiosis I occurring in (T9H/+, Tyr^c ^/c, ICR^Δ/+ ♀×T9H/+, Tyr ^+/+, ICR^+/+ ♂) matings. Female reciprocal translocation heterozygote (T9H/+) parent is homozygous for the dist7 marker albino (Tyr^c ^/c) and carries ICR^Δ (ICR^Δ/+), while the male T9H/+ parent is wild-type at both of these loci (Tyr ^+/+, ICR^+/+). (B) Genotypes of MatDup.dist7 fetuses obtained from the union of unbalanced complementary gametes. MatDup.dist7 individuals are readily identified as albinos from 12½ dpc by lack of eye or fur pigmentation. Many of these are ICR^Δ.+ although a high frequency of homozygous recombinants, ICR^Δ.Δ and ICR^+.+, are also obtained. Chrs depicted are actually paired chromatids. Underneath is depicted allele-specific expression—MatDup.dist7 ICR^Δ.+ and ICR^Δ.Δ fetuses have one and probably two activated Igf2 alleles, and should have one and two repressed H19 alleles, respectively.