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Seeded PrP polymerization mechanisms. In the non-catalytic model, the conformational interchange between the PrPC and PrPRES conformations is rapid, but the PrPRES conformer is poorly populated unless stabilized by binding to an existing PrPRES multimer. In the autocatalytic model, the conformational conversion of PrPC to PrPRES is rare unless catalyzed by contact with an existing PrPRES multimer.
