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. 2009 Dec 30;4(12):e8494. doi: 10.1371/journal.pone.0008494

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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In panels A (anti-peptide B) and B (anti-dsDNA), the pre-immune OD 450 nm values are shown in light blue and the responses after each boost are shown in distinct colors. The low pre-immune values were not subtracted from the post-immune values shown. C. Mean responses of GR-, BB- and CF- immunized rabbits showing high and low anti-dsDNA responders (ds) among GR-MAP-8 immunized rabbits. Each symbol represents an individual rabbit serum tested prior to immunization (Pre ds), after the 3^rd, 5^th and intravenous (iv) boosts.