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. 2009 Dec 30;4(12):e8494. doi: 10.1371/journal.pone.0008494

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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An overview of key ancestors, autoantibody responses, and the relationship of males (large squares) and females (large circles) in the current (group 6) to rabbits in 5 earlier groups is shown. Colors in the four quadrants indicate postimmunization elevations of levels of anti-dsDNA (blue, upper left), anti-Sm and/or anti-RNP (yellow, lower left), ANA by IFA (red upper right) and ANA by ELISA (brown diagonal lines, lower right). For the previous group 5 [9] and present group 6 animals, darker colors indicate high autoantibody responses (Tables 3).