Table 3. Summary of mRNA expression data and autoantibody responses.* .
| Q-PCR | ELISA | IFA | |||||||||||||||||||||||||
| BR3 | BAFF | B2M | dsDNA | Peptide | Sm | RNP | ANA | ANA | |||||||||||||||||||
| Rabbit | Pre | 3rd | 5th | Pre | 3rd | 5th | Pre | 3rd | 5th | Pre | 3rd | 5th | Pre | 3rd | 5th | Pre | 3rd | 5th | Pre | 3rd | 5th | Pre | 3rd | 5th | Pre | 3rd | 5th |
| UA345-5(GR72) | 81.01 | 18.51 | 6.06 | 2.16 | 44 | 177.33 | 0.067 | 1.87 | 0.10 | 0.75 | 0.15 | 0.43 | 0.22 | 0.47 | 1.13 | 1.68 | 1 | 1 | 1 | ||||||||
| UA269-3(GR73) | 35.02 | 16.00 | 24.25 | 1.69 | 1.68 | 2.11 | 29.42 | 1 | 0.086 | 2.28 | 2.03 | 0.07 | 1.09 | 1.22 | 0.57 | 0.60 | 0.57 | 0.56 | 0.62 | 0.56 | 0.75 | 1.15 | 1.22 | 2 | 3 | 3 | |
| 2YY119-9(GR76) | 27.47 | 15.14 | 2.08 | 2.64 | 78.86 | 188.97 | 0.074 | 1.94 | 0.09 | 1.07 | 0.20 | 0.63 | 0.22 | 0.49 | 0.47 | 0.90 | 1 | 2 | |||||||||
| UA269-1(GR77) | 29.86 | 32.90 | 26.35 | 1.42 | 2.22 | 2.16 | 55.39 | 55.92 | 0.161 | 1.90 | 0.99 | 0.07 | 1.19 | 1.10 | 0.15 | 0.34 | 0.25 | 0.27 | 1.05 | 0.57 | 0.47 | 0.77 | 0.98 | 1 | 3 | 4 | |
| XA345-1 (GR80) | 28.05 | 25.81 | 31.56 | 1.87 | 2.25 | 2.19 | 39.68 | 32.45 | 0.334 | 0.44 | 0.36 | 0.22 | 1.27 | 1.63 | 0.12 | 0.22 | 0.17 | 0.40 | 1.04 | 0.51 | 0.37 | 0.37 | 0.38 | 1 | 1 | 1 | |
| 2UA14-2(GR81) | 33.13 | 18.77 | 24.76 | 1.37 | 1.47 | 2.08 | 30.1 | 74.91 | 0.26 | 0.49 | 0.47 | 0.15 | 1.82 | 1.66 | 0.12 | 0.20 | 0.17 | 0.13 | 0.18 | 0.20 | 0.30 | 0.88 | 1.28 | 1 | 1 | 1 | |
| XA234-6 (GR84) | 17.63 | 30.27 | 21.41 | 0.71 | 2.71 | 2.28 | 28.43 | 28.42 | 0.126 | 0.17 | 0.22 | 0.20 | 1.95 | 2.07 | 0.29 | 0.31 | 0.29 | 0.22 | 0.23 | 0.22 | 0.38 | 0.76 | 0.87 | −1 | 1 | 1 | |
| XA346-1 (GR85) | 43.11 | 39.40 | 43.11 | 1.19 | 2.83 | 2.03 | 10.6 | 27.6 | 0.128 | 0.21 | 0.30 | 0.22 | 2.17 | 2.16 | 0.25 | 0.35 | 0.25 | 0.91 | 2.48 | 1.98 | 0.47 | 1.26 | 1.37 | −1 | 4 | 4 | |
| 6YY328-4(BB74) | 30.48 | 25.28 | 2.99 | 4.08 | 90.56 | 65.99 | 0.07 | 0.08 | 0.08 | 0.08 | 0.18 | 0.19 | 0.19 | 0.24 | 2.02 | 1.89 | 1 | 1 | |||||||||
| 2YY125-6(BB75) | 41.07 | 26.54 | 9.65 | 2.22 | 2.00 | 1.68 | 6.89 | 42.37 | 0.09 | 0.11 | 0.09 | 0.07 | 0.07 | 0.08 | 0.22 | 0.31 | 0.23 | 0.19 | 0.23 | 0.21 | 0.52 | 0.82 | 0.63 | −1 | 3 | 1 | |
| YY118-6(BB78) | 50.56 | 34.54 | 1.79 | 2.38 | 43.86 | 35.75 | 0.07 | 0.07 | 0.12 | 0.12 | 0.14 | 0.17 | 0.65 | 0.65 | 1.61 | 1.74 | 1 | 2 | |||||||||
| 1UA161-2(BB79) | 63.12 | 38.59 | 23.59 | 1.39 | 1.91 | 1.45 | 36.62 | 20.81 | 0.07 | 0.08 | 0.09 | 0.07 | 0.07 | 0.07 | 0.14 | 0.16 | 0.24 | 0.17 | 0.33 | 0.36 | 0.29 | 0.52 | 0.41 | 1 | 1 | 1 | |
| XA346-2 (BB82) | 37.79 | 30.27 | 21.41 | 1.40 | 2.07 | 3.34 | 63.41 | 32.26 | 0.48 | 0.48 | 0.48 | 0.18 | 0.31 | 0.24 | 0.16 | 0.28 | 0.32 | 0.16 | 0.21 | 0.20 | 0.51 | 1.61 | 1.42 | 1 | 3 | 3 | |
| 2UA14-3(BB83) | 29.86 | 29.65 | 23.10 | 0.91 | 2.48 | 2.57 | 38.11 | 47.46 | 0.26 | 0.59 | 0.41 | 0.17 | 0.25 | 0.17 | 0.11 | 0.23 | 0.29 | 0.17 | 0.29 | 0.22 | 0.44 | 0.66 | 0.64 | 1 | 3 | 3 | |
| XA234-2(BB86) | 34.78 | 56.49 | 50.91 | 1.35 | 2.25 | 3.84 | 16.38 | 20.21 | 0.12 | 0.73 | 1.37 | 0.16 | 0.19 | 0.17 | 0.18 | 0.28 | 0.18 | 0.19 | 0.28 | 0.20 | 0.26 | 0.29 | 0.36 | −1 | 1 | 1 | |
| 3XA203-2(BB87) | 52.71 | 45.57 | 60.13 | 0.71 | 1.29 | 1.48 | 13.38 | 20.34 | 0.13 | 0.16 | 0.16 | 0.22 | 0.22 | 0.22 | 0.16 | 0.21 | 0.20 | 0.16 | 0.22 | 0.18 | 0.36 | 1.61 | 1.06 | −1 | −1 | 1 | |
| 6YY328-3(CF1) | 66.72 | 31.34 | 2.00 | 3.14 | 58.33 | 17.59 | 0.29 | 0.29 | 0.13 | 0.13 | 0.19 | 0.19 | 0.24 | 0.24 | 1.11 | 1.48 | 1 | 2 | |||||||||
| 1UA161-1(CF2) | 11.96 | 28.05 | 20.39 | 1.07 | 1.39 | 2.31 | 59.9 | 8.75 | 0.09 | 0.09 | 0.09 | 0.08 | 0.08 | 0.08 | 0.20 | 0.28 | 0.26 | 0.18 | 0.22 | 0.20 | 0.76 | 0.99 | 0.92 | 1 | 2 | 1 | |
| 1YY125-4(CF3) | 63.56 | 51.63 | 1.47 | 2.31 | 29.98 | 38.42 | 0.21 | 0.24 | 0.13 | 0.13 | 0.13 | 0.19 | 0.14 | 0.15 | 1.12 | 1.12 | 1 | 3 | |||||||||
| 2YY125-4(CF4) | 36.50 | 20.53 | 18.25 | 1.58 | 1.77 | 1.75 | 16.88 | 5.1 | 0.12 | 0.12 | 0.12 | 0.11 | 0.11 | 0.11 | 0.26 | 0.26 | 0.26 | 0.23 | 0.26 | 0.23 | 0.76 | 0.87 | 0.76 | 1 | 1 | 1 | |
| XA345-2 (CF5) | 16.91 | 14.93 | 17.63 | 1.55 | 1.83 | 3.78 | 36.87 | 50.38 | 0.24 | 0.36 | 1.28 | 0.24 | 0.24 | 0.26 | 0.12 | 0.14 | 0.13 | 0.16 | 0.17 | 0.16 | 0.54 | 0.58 | 0.59 | −1 | −1 | 1 | |
| 2XA344-2 (CF6) | 20.39 | 15.24 | 21.56 | 1.72 | 3.01 | 3.23 | 27.06 | 38.58 | 0.37 | 0.37 | 0.37 | 0.28 | 0.28 | 0.28 | 0.40 | 0.58 | 0.49 | 0.31 | 0.44 | 0.33 | 1.96 | 1.96 | 1.96 | −1 | 1 | 1 | |
| 1XA344-1 (CF7) | 30.48 | 34.54 | 31.56 | 1.85 | 2.58 | 2.62 | 18.2 | 48.57 | 0.10 | 0.11 | 0.11 | 0.18 | 0.25 | 0.18 | 0.20 | 0.24 | 0.23 | 0.17 | 0.25 | 0.20 | 0.21 | 0.31 | 0.30 | −1 | 1 | −1 | |
*
Bold shows values of at least 0.1 (for ELISA) or 1 [for Q-PCR and ANA (IFA)] above the pre-immune values. Italics show values of at least 1 (for Q-PCR) below pre-immune values.