Table 1. Mice hemodynamics.
Vehicle | Leucine | |||||||||
siRNAGFP | siRNAMEF2C | siRNAGFP | siRNAMEF2C | |||||||
SO | TAC 7days | TAC 15 days | SO | TAC 7 days | TAC 15 days | SO | TAC 7days | SO | TAC 7days | |
N | 11 | 12 | 7 | 11 | 7 | 10 | 9 | 8 | 7 | 9 |
SBPa(mmHg) | 123±3 | 171±3* | 177±4* | 121±3 | 171±3* | 171±6* | 138±3 | 171±6# | 145±4 | 160±6# |
SBPf (mmHg) | 119±2 | 128±4 | 124±3 | 125±5 | 123±2 | 129±4 | ||||
SGr | 52±2 | 49±3 | 46±1 | 46±5 | 48±5 | 43±2 | ||||
HR (beats/min) | 397±22 | 420±16 | 377±26 | 436±15 | 365±19 | 365±26 | 415±15 | 422±12 | 443±11 | 402±9 |
SO. Sham operated; TAC. transverse aorta constricted; SBPa. systolic blood pressure in ascending aorta; SBPf. systolic blood pressure in femoral artery; SGr. systolic gradient; HR. heart rate.
*P<0.05 indicated statistical significance compared to values of SO mice treated whit vehicle.
# P<0.05 indicated statistical significance compared to values of SO mice treated whith leucine.