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. 2009 Dec 24;4(12):e8445. doi: 10.1371/journal.pone.0008445

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A, B) The bar graphs show the relative quantity of G1/S and G2/S ratio between the non-specific miRNA (negative control) and miR-24 transfected cells. MiR-24 transfection induced a G2-cell cycle arrest. (C, D) miR-24 increases the expression of cell cycle control genes p53 and p21 in HCT 116 (wt-p53) and U-2 OS cells as determined by Western blotting. (E) In p53 null HCT-116 cells, independent of p21, miR-24 inhibited the G2 arrest (B and E).