Table 2.

Probabilities and Utilities

Probabilities	Base-Case Analysis	Sensitivity Analysis		Timeframe
		Low	High
Monthly mortality rate*
Not castrate†	0.063	0.039	0.077
Incomplete castration (fixed or individualized)†	0.058	0.039	0.077
Castrate (medical or surgical)†	0.053	0.039	NA
True castrate on LH-RHa‡	0.95	0.9	0.99
Elect orchiectomy§	0.75	0.5	0.9
Quality-of-life weights
Utility‖
Not castrate	0.800	0.7	0.9	Life
Incomplete castration	0.750	0.65	0.85	Life
Castrate	0.750	0.65	n/a	Life
Surgical absence of testes	0.700	0.6	0.8	Life
Disutility‖
Oral antiandrogen treatment	−0.025	−0.05	0	1 month, repeating
Orchiectomy	−0.200	−0.4	0	1 month
LH-RHa administration	0	−0.025		1 month, repeating
Testosterone monitoring	0	−0.025		1 month, repeating

Abbreviations: LH-RHa, luteinizing hormone–releasing hormone agonist; NA, not applicable.

^*More than one variable was adjusted when necessary (i.e., ordered or ranked health states were modified together if needed to preserve their order or rank).

^†Taylor, Elson, and Trump³; Halabi et al¹²; Petrylak et al²⁹; Tannock et al³⁰; and Hussain et al.³⁵

^‡Oefelein and Cornum.¹⁹

^§Estimate.

^‖Chon, Jacobs, and Naslund⁴; Oefelein⁷; Mariani, Glover, and Arita²³; Krahn et al³⁶; Nygard, Norum, and Due³⁷; and M. Krahn (personal communication, November 2004).