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The EC50 of substrate and IC30 values (±S.E.) for NAAA inhibition of glycine transport by wild type and chimeric transporters
| Transporter | EC50 |
IC30 |
||||
|---|---|---|---|---|---|---|
| Glycine | Sarcosine | NAGly | NALAla | NADAla | NAGABA | |
| μm | μm | |||||
| GLYT2 | 18 ± 2 | 3.4 ± 0.6 | 5.9 ± 0.7 | 17 ± 2 | 22 ± 4 | |
| GLYT2(EL2) | 19 ± 2 | 28 ± 4 | 6 ± 1 | >30 | >30 | |
| GLYT2(EL4) | 24 ± 2 | >30 | >30 | >30 | >30 | |
| GLYT1 | 22 ± 2 | 13 ± 1 | >30 | >30 | >30 | >30 |
| GLYT1(EL4) | 139 ± 2 | 228 ± 11 | >30 | 21 ± 2 | >30 | 35 ± 9 |
| GLYT1(EL2,EL4) | 176 ± 8 | 209 ± 8 | >30 | 22 ± 5 | ||
