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. Author manuscript; available in PMC: 2009 Dec 16.
Published in final edited form as: Steroids. 2006 Dec 13;72(2):171–179. doi: 10.1016/j.steroids.2006.11.005

Fig. 7.

Fig. 7

A proposed molecular model for the liganded TRβ1-dependent SRC-3/PA28γ activated degradation of PTTG (A). The direct interaction of TRβ1 with SRC-3 induced by the binding of T3 results in the formation of liganded TRβ1/PTTG/SRC-3/PA28γ complexes that activate the degradation of PTTG. The degradation of PTTG leads to timely separation of sister chromatids. (B). PV also forms complexes with PTTG. But because PV does not bind T3, PV cannot directly bind to SRC-3/PA28γ to activate degradation. The absence of degradation leads to elevated PTTG and results in inhibition of mitotic progression [49].