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Activation of muscarinic M1 receptors by analogues of AC-260584 as measured by R-SAT
| M1 Agonist RSAT | ||
|---|---|---|
| pEC50 | %Efficacy | |
| AC-260515 | 6.6 ± 0.2 | 66 ± 16 |
| AC-262469 | 7.2 ± 0 | 107 ± 16 |
| AC-260977 | 7.7 ± 0.1 | 107 ± 10 |
Activities of AC-260584 analogues on human M1 receptors were assessed using R-SAT in transiently transfected NIH-3T3 cells. Data presented are mean ± SD from 5-7 independent experiments carried out in triplicate.
