Table 4.
M1 Agonist RSAT | ||
---|---|---|
pEC50 | %Efficacy | |
AC-260515 | 6.6 ± 0.2 | 66 ± 16 |
AC-262469 | 7.2 ± 0 | 107 ± 16 |
AC-260977 | 7.7 ± 0.1 | 107 ± 10 |
Activities of AC-260584 analogues on human M1 receptors were assessed using R-SAT in transiently transfected NIH-3T3 cells. Data presented are mean ± SD from 5-7 independent experiments carried out in triplicate.