Table I.
Examples of Reactions during Peanut OIT Home Dosing
| Subject | Age at reaction (months) |
Pattern | Reaction | Dose | Length of time on OIT (months) |
Length of time on dose |
Baseline IgE (kU/L) |
IgE at time of reaction |
Treatment | Recommendations to this subject |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 70 | Fever | AE, LR | 300 mg |
12 | 5 months | 23.6 | 13.9 | H1, E, A | Hold dose if ill |
| 2 | 131 | Fever | AE, U, LR | 1200 mg |
19 | 3 months | >100 | 136.5 | H1, E, CS, A |
Hold dose if ill |
| 3 | 38 | Asthma | LR | 300 mg |
10 | 4 months | 22.7 | 9.3 | H1, A | Start inhaled CS |
| 4 | 83 | Empty stomach |
U, LR, G | 1800 mg |
27 | 7 months | >100 | 115 | H1, A | Take all doses with meal |
| 5 | 102 | Exertion | LR | 2400 mg |
49 | 2 months | 58.3 | 4.7 | H1, A | Avoid exercise for 2 hours after dose |
| 6 | 99 | Exertion | U, LR | 3000 mg |
47 | 2 days | 73.1 | 7.3 | H1,CS | Avoid exercise for 2 hours after dose; decrease dose to 2400 mg |
| 7 | 145 | Menses and exertion |
AE,U, UR, LR, G |
4000 mg |
20 | 9 months | 85.1 | 59.5 | H1, E, CS | Discontinued participation in study after 2nd occurrence |
AE = angioedema
U = urticaria
UR = upper respiratory
LR = lower respiratory
G = gastrointestinal
IgE = immunoglobulin E
H1 = H1 antagonist
E = epinephrine
CS = corticosteroids
A = albuterol