Table II.

Recommendations for Future OIT Investigations

Hold daily dose if febrile or ill with symptoms of viral illness (e.g., upper respiratory infection, gastroenteritis) Resume dosing at home if < 3 missed daily doses Return to research unit for observed dose if 3–5 missed daily doses Consider repeat desensitization or significant dose reduction if more than 5 missed daily doses Closely monitor lower and upper respiratory symptoms Initiate asthma controller medication if needed Perform peak flow and spirometry monitoring Ensure optimal control of allergic rhinitis Take daily OIT dose with meal or snack In subjects with exercise-induced symptoms, limit exertion for 2 hours post-dosing Closely monitor during menstrual cycle – especially when coupled with infection or exercise