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. Author manuscript; available in PMC: 2010 Dec 14.
Published in final edited form as: Cancer Res. 2009 Dec 15;69(24):9163–9168. doi: 10.1158/0008-5472.CAN-09-2483

Figure 1.

Figure 1

NGAL protein expression correlates with ErbB2 status in vivo and in vitro. A, Western blot analysis revealed that breast cancer cell lines stably overexpressing ErbB2 secreted more NGAL in conditioned media than vector control cell lines. B, Mammary tumors from MMTV-neu mice had higher NGAL expression than MMTV-PyMT mice. C, following trastuzumab (Ttzm) treatment, Western blot analysis in 231BR.vec and 231BR.erbB2 cells confirmed that NGAL production was dependent on high ErbB2 expression levels. D, after ErbB2 is downregulated by MAb 7.16.4, NGAL protein expression in mammary tumors decreased in MMTV-neu transgenic mice. CB, Coomassie Blue staining.