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. Author manuscript; available in PMC: 2011 Jan 21.
Published in final edited form as: FEBS Lett. 2010 Jan 21;584(2):318–324. doi: 10.1016/j.febslet.2009.11.056

Figure 1.

Figure 1

Structural model of the B. subtilis tyrS leader RNA. The sequence is shown (and numbered) from the transcription start-point through the end of the leader region transcriptional terminator (U274); the coding sequence for TyrRS is further downstream. The structural model of the terminator conformation is shown; the alternate antiterminator conformation is shown above the terminator element. Structural domains (Stem I, Stem II, Stem IIA/B pseudoknot, Stem III) and conserved sequence and structural elements (GA motif, S-turns, AG bulge, Specifier Loop, T box) are labeled. Residues that are highly conserved are marked with asterisks (*). The pseudoknot pairing is shown in purple. Sequences on the 5′ side of the terminator (blue) also participate in pairing with a portion of the T box sequence (red) to form the antiterminator helix. The Specifier sequence residues (UAC tyrosine codon) are boxed. Residues that participate in pairing with the tRNA (UACA in the Specifier Loop, UGGU in the antiterminator bulge) are shown in green.