Table 3.
Effects of REV3, RAD30 single or double deletion(s) on Me-lex (6 mM, 12 mM) induced p53 mutant frequencies.
| Strain | genotype | p53 mutant frequency (red colonies/total) ×103 |
statistics |
|---|---|---|---|
| Me-lex induced (6 mM) | |||
| yIG397 | WT |
10.7 (301/28.043)*§# |
*p<0.0004; §p<0.0023; #p<0.0001 |
| yPM6 | rev3 |
2.89 (7/2.421)*^† |
^p<0.0054; †NS |
| yPM13 | rad30 |
8.3 (303/36.319)§^** |
**p<0.0001 |
| yPM14 | rev3rad30 |
2.2 (12/5.459)#†** |
|
| Me-lex induced (12 mM) | |||
| yIG397 | WT |
28.36 (155/5.466)*§# |
*NS; §p<0.0009; #p<0.015 |
| yPM6 | rev3 |
17.87 (6/336)*^† |
^p<0.05; †NS |
| yPM13 | rad30 |
42.6 (129/3.024)§^** |
**p<0.0005 |
| yPM14 | rev3rad30 |
8.25 (4/485)#†** |
NS: not significant