Table 2.
UGDH expression in the acini/epithelial cells of biopsy specimens
| # Average of corrected MPI ± STDEV | Δ p values | |||||
|---|---|---|---|---|---|---|
| Prostate Cancer Cases |
||||||
| Patient prostate core biopsies in matched pairs | Non Prostate Cancer Control Cases Normal Acini (NA) | Cancerous Acini (CA) | Normal Appearing Acini (NAA) | ¥ NA vs. CA | Φ CA vs. NAA | † NA vs. NAA |
| 1 | 458.2 ± 33.5 | 445.5 ± 137.6 | 606.0 ± 358.6 | >0.05 | <0.01 | <0.01 |
| 2 | 479.5 ± 67.2 | 352.4 ± 13.3 | 446.1 ± 24.1 | <0.01 | <0.01 | >0.05 |
| 3 | 470.7 ± 86.2 | 744.2 ± 26.6 | 487.2 ± 52.2 | <0.01 | <0.01 | >0.05 |
| 4 | 453.0 ± 142.3 | 880.8 ± 43.8 | 424.15 ± 75.0 | <0.01 | <0.01 | <0.01 |
| 5 | 605.3 ± 0.7 | 684.4 ± 61.2 | 449.0 ± 37.2 | <0.01 | <0.01 | <0.01 |
| 6 | 451.0 ± 5.3 | 845.1 ± 179.7 | 588.6 ± 35.7 | <0.01 | <0.01 | <0.01 |
| 7 | 737.2 ± 49.4 | 414.0 ± 25.2 | 618.4 ± 79.3 | <0.01 | <0.01 | <0.01 |
| 8 | 779.3 ± 10.8 | 705.6 ± 163.3 | 348.3 ± 75.1 | >0.05 | <0.01 | <0.01 |
| 9 | 574.1 ± 4.0 | 876.1 ± 43.4 | 660.2 ± 155.0 | <0.01 | <0.01 | 0.02 |
| 10 | 633.1 ± 50.2 | 653.2 ± 7.5 | 435.8 ± 17.0 | >0.05 | <0.01 | <0.01 |
| 11 | 430.7 ± 114.7 | 843 ± 43.4 | 488.9 ± 79.3 | <0.01 | <0.01 | <0.01 |
| 12 | 451.2 ± 10.1 | 552.6 ± 6.1 | 293.5 ± 14.9 | <0.01 | <0.01 | <0.01 |
| 13 | 548.6 ± 61.4 | 611.1 ± 55.0 | 490.3 ± 46.9 | <0.01 | <0.01 | >0.05 |
| 14 | 568.5 ± 4.3 | 1113.0 ± 30.9 | 563.7 ± 89.8 | <0.01 | <0.01 | >0.05 |
| 15 | 498.3 ± 71.6 | 735.5 ± 150.7 | 436.3 ± 121.9 | <0.01 | <0.01 | <0.01 |
| 16 | 512.1 ± 9.0 | 452.1 ± 2.0 | 292.5 ± 0.4 | <0.01 | <0.01 | <0.01 |
| 17 | 605.4 ± 35.3 | 909.3 ± 15.2 | 571.0 ± 11.4 | <0.01 | <0.01 | >0.05 |
| 18 | 591.5 ± 104.4 | 718.1 ± 99.6 | 392.3 ± 5.3 | <0.01 | <0.01 | <0.01 |
| 19 | 636.5 ± 105.6 | 536.15 ± 60.5 | 409.4 ± 74.0 | <0.01 | <0.01 | <0.01 |
| 20 | 392.2 ± 23.3 | 503.7 ± 88.9 | 485.0 ± 113.4 | <0.01 | >0.05 | <0.01 |
| 21 | 469.6 ± 8.1 | 742.2 ± 42.1 | 565.8 ± 22.9 | <0.01 | <0.01 | <0.01 |
| 22 | 762.5 ± 92.7 | 961.0 ± 22.1 | 447.0 ± 93.6 | <0.01 | <0.01 | <0.01 |
| 23 | 424.9 ± 12.8 | 813.5 ± 29.3 | 474.5 ± 76.5 | <0.01 | <0.01 | <0.01 |
| 24 | 676.1 ± 19.8 | 407.7 ± 47.2 | 470.2 ± 40.1 | <0.01 | <0.01 | <0.01 |
| 25 | 598.4 ± 75.6 | 561.0 ± 86.3 | 407.4 ± 34.6 | >0.05 | <0.01 | <0.01 |
| 26 | 571.6 ± 89.4 | 475.8 ± 28.1 | 272.5 ± 35.0 | <0.01 | <0.01 | <0.01 |
| 27 | 422.4 ± 42.8 | 661.3 ± 4.9 | 392.6 ± 4.6 | <0.01 | <0.01 | >0.05 |
| 28 | 557.8 ± 60.7 | 647.4 ± 14.2 | 447.6 ± 61.7 | <0.01 | <0.01 | <0.01 |
| 29 | 447.7 ± 43.6 | 633.2 ± 15.4 | 501.7 ± 1.8 | <0.01 | <0.01 | <0.01 |
| 30 | 578.3 ± 15.3 | 448.5 ± 42.4 | 475.4 ± 37.1 | <0.01 | <0.01 | <0.01 |
| 31 | 552.9 ± 82.9 | 792.5 ± 45.4 | 463.3 ± 58.2 | <0.01 | <0.01 | <0.01 |
| 32 | 478.6 ± 41.8 | 570.9 ± 281.3 | 439.3 ± 1.0 | <0.01 | <0.01 | <0.01 |
Δ
Significance of differences was determined by a two-tailed Student’s t-test between two samples with unequal variance
#
Average of the background corrected Mean pixel intensity (MPI) of UGDH labeling in individual acini
¥
Cancerous acini (CA) compared to non-cancerous acini (NA) of the matched controls
Φ
Normal appearing acini (NAA) in cancerous glands compared to cancerous acini (CA) of the same gland
†
NAA in cancerous glands compared to non-cancerous acini (NA) of the matched controls