Skip to main content
. Author manuscript; available in PMC: 2011 Jan 15.
Published in final edited form as: Biol Psychiatry. 2010 Jan 15;67(2):168–174. doi: 10.1016/j.biopsych.2009.08.017

Table 1.

Schedule of Treatments and Tests

Group Day 1 Days 5-6 Day 8 Days 9-11 Days 12-13 Day 14 Day 15
NS/OIL OVX1 OIL2 NS3 DW4 OIL+
DW		 DW perfusion (n=4)
AE5 (n=8)
NS/EB OVX OIL NS DW EB6+
DW		 DW perfusion (n=4)
AE (n=7)
OIL/IES OVX OIL IES7 DW OIL+
DW		 DW perfusion (n=4)
AE (n=8)
EB/IES OVX EB IES DW OIL+
DW		 DW perfusion (n=4)
AE (n=7)
IES1d OVX OIL DW OIL+
DW		 IES+
DW		 perfusion (n=4)
AE (n=8)
IES/DMI OVX OIL IES DMI8 OIL+
DMI		 DMI perfusion (n=4)
AE (n=8)
1

Ovariectomy;

2

Oil vehicle treatment (sesame oil, 1 ml/kg, s.c.);

3

Non-stress exposure (the animals were placed in the shuttle box but did not receive footshock);

4

Distilled water vehicle treatment (1 ml/kg, twice daily, i.p.);

5

Active escape testing;

6

Estradiol treatment (estradiol benzoate in sesame oil, 40 μg/kg, s.c.);

7

Stress exposure (60 inescapable footshocks in the shuttle box);

8

Antidepressant treatment (desipramine in distilled water, 10 mg/kg, twice daily, i.p.).