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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Ann Rheum Dis. 2010 Jan;69(1):43–47. doi: 10.1136/ard.2008.101378

Table 4.

Adjusted* Relationship between Selected Risk Factors for Elevated Liver Enzyme Tests among Psoriatic Arthritis Patients**

Covariate OR (95% CI)

Methotrexate (mg/week)

  None 1.0 (referent)

  2.5 – 7.5 1.23 (0.25 – 5.9)

  10 – 12.5 3.04 (0.70 – 13.29)

  ≥ 15 2.37 (0.81 – 6.92)

Anti-TNF use (referent to no use) 0.82 (0.31 – 2.17)

Body mass index
  < 25 1.0 (referent)
  25–30 2.97 (0.77 – 11.41)
  > 30 3.09 (0.84 – 11.45)

Current Tobacco use 1.35 (0.40 – 4.55)

History of liver disorder 4.96 (0.95 – 25.90)

  Number of liver enzyme test blood draws*** 1.22 (0.53 – 2.84)

Alcohol use

  None / occasional 1.0 (referent)
  1–3 / week 1.22 (0.46 – 3.24)
  ≥ 1 / day 2.18 (0.52 – 9.15)

OR = Odds Ratio; PsA = psoriatic arthritis; RA = rheumatoid arthritis; BMI = body mass index

*

similar to Table 3, additional covariates adjusted for included age, gender, duration of disease, number of physician visits, NSAID use, recent hospitalization, an interaction term between PsA and alcohol, and folate supplementation

**

Defined as AST or ALT greater than the upper limit of the laboratory normal

***

during observation period