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. Author manuscript; available in PMC: 2010 Dec 22.
Published in final edited form as: Biochemistry. 2009 Dec 22;48(50):11872–11882. doi: 10.1021/bi9014488

Figure 7. Voltage dependence of A/M2 inhibition by amantadine, BL-1743, spiran amine.

Figure 7

8 and spiro piperidine 20. Inhibition of A/M2 channel activity by amantadine, BL-1743, spiran amine 8 and spiro piperidine 20 was assayed at various holding voltages (from −40mV to +40mV). The mean (±SD) channel activity remaining after the maximal inhibition by each of the inhibitors (100 μM) was achieved was plotted as a function of the holding voltage. The experimental data are the average of three independent experiments. Each point is a mean (±SD) of 6–10 oocytes.