Figure 4. Down-regulation of CXCR1 and/or CXCR2 reduces cell motility and invasion.
A, Cells were seeded on non-coated or Matrigel-coated membranes for motility (upper panel) and invasion (lower panel) assays overnight. Migrated cells were stained and photographed at 200× magnification. B, Migrated (left panel) and invaded (right panel) cells were counted in ten random fields (200×) and expressed as the average number of cells per field of view ± SEM. This is a representative of three experiments done in triplicate. *Significantly different from SM-control cells (p<0.05).