Fig. 1.

Identification of genetic variants of CYP2D6 with mutations in putative targeting signals. (A and B) Total RNA was extracted from human liver samples and the first 600 nucleotides of the coding region were amplified by RT-PCR. The amplified DNA was cloned and sequenced. (A) Schematic representations of point mutations identified in the human liver samples. (B) Schematic representations of splice variants identified. The deleted or skipped exon regions are shown as hatched boxes.