Table 2.
Distribution of CYP2D6 between mitochondria and microsomes isolated from human liver samplesc.
| Liver Sample | Mitochondria (% total CYP2D6) |
Microsomes (% total CYP2D6) |
|---|---|---|
| HL123 | 46.1 | 53.9 |
| HL127 | 47.3 | 52.7 |
| HL130 | 47.4 | 52.6 |
| HL136d | 20 | 80 |
| HL141d | 1.1 | 98.9 |
c
Measured by densitometric analysis of immunoblots performed on mitochondria and microsomes isolated from human liver samples.
d
Densitometric measurements for distribution of CYP2D6 between mitochondria and microsomes in HL136 and HL141 were published earlier in [12].