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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Cell Signal. 2010 Mar;22(3):386–394. doi: 10.1016/j.cellsig.2009.10.008

Fig. 5. A working model for the role of USP11 in the negative regulation of TNFα-mediated IκBα ubiquitination and NF-κB activation.

Fig. 5

TNFα induces IKKβ-mediated IκBα phosphorylation and ubiquitination. USP11 is constitutively associated with IκBα and acts as an IκBα deubiquitinase to inhibit TNFα-induced IκBα ubiquitination and degradation. USP11 plays a critical role in the downregulation of the NF-κB activation, probably along with USP15.