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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Mol Genet Metab. 2010 Jan;99(1):62–71. doi: 10.1016/j.ymgme.2009.08.002

Figure 3.

Figure 3

Representative histopathology of tissues from 30-week-old Idua-W392X mice. Arrows indicate inclusions representing GAG accumulation in (A) the cytoplasm of Purkinje cells in the cerebellum; and (B) the cytoplasm of a neuron in the medulla. Foamy macrophages distended by GAG accumulation are observed in (C) liver, (D) spleen, (E) myocardium, (F) aorta, (G) kidney, and (H) lung. Panels A and B were stained with PAS-hematoxylin, original magnification 80X; Panels C, F, G, and H were stained with HE, original magnification 20X; Panels D and E were strained with HE, original magnification 40X.