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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Psychoneuroendocrinology. 2009 Dec;34S1:S178–S185. doi: 10.1016/j.psyneuen.2009.06.001

Figure 2. Differential effects of neuroactive steroid analogues on T-type calcium currents and GABAA-gated currents.

Figure 2

Panels A–C on the left show the effects of selected neuroactive steroids on T-type currents in acutely dissociated DRG cells. Panels A–C on the right show the effects of the same steroids on GABAA-gated currents in cultured hippocampal neurons (A and C) or in xenopus oocytes (panel B).Note that ECN (panel A) inhibited T-type current but had no apparent effects on GABAA currents, while in contrast, CDNC24 (panel B) had no effect on T-type current but potentiated GABAA-gated currents. ACN (panel C) had an effect on both currents as evidenced by the inhibition of T-type current and marked potentiation of GABAA-gated currents. (Reproduced with permission from Todorovic et al., Molecular Pharmacology, 54: 918–927, 1998 – Figs. 2A, 2B, 3A and 9A; Pathirathna et al., Pain, 114: 429–443, 2005- Fig. 8 – top and middle panels).