Table 2.
FICZ- and TCDD-induced changes in expression of selected transcripts in XLK-WG cells. Numbers indicate fold induction relative to vehicle-treated control.
| Transcript (unigene ID*) | FICZ | TCDD | ||
|---|---|---|---|---|
| Microarray | qRT-PCR | Microarray | qRT-PCR | |
| CYP1A7 (Xl.1220) | 16.1 | 412.1 | 6.7 | 320 |
| CYP1A6 (Xl.1692) | 2.1 | 455.3 | 1.7 | 427.3 |
| SYNE 1 (Xl. 14119) | 6.7 | 106 | 8.4 | |
| Xl.7783 | 5.9 | 4.3 | 2.0 | |
| MGC52735:similar to gap-jct protein alpha-7 (Xl.3337) | 5.2 | 304 | 69.1 | |
| Xl.14954 (similar to voltage-gated potassium channel subunit MiRP4.1) | 3.1 | 9.5 | 6.6 | |
| Xl.13754 (similar to C219-reactive peptide) | 3.1 | 4.6 | 2.2 | |
| Thyrotropic emvbryonic factor (TEF; Xl.16518) | 2.2 | 2.2 | 1.7 | |
| Peripheral Myelin protein 22 (Xl.11939/Xl.14729) | 2.2 | 1.0 | 1.1 | |
| MGC85390 (Xl.23887; similar to RAB 40B, RAS oncogene family) | 2.1 | 1.3 | 2.0 | |
| Xl.25142 | 2.1 | 1.8 | 0.9 | |
| Xl.14954 | 2.1 | 1.9 | 3.0 | |
| KCNE5.1: voltage-gated potassium channel subunit MiRP4.1 (Xl.16370) | 2.0 | 1.6 | 2.0 | |
| Hyaluronidase 2 (Xl.6247/Xl.16152) | 1.5 | 2.7 | 1.3 | 1.6 |
| Hypothetical protein MCG81225 (similar to Zn-finger protein 410; Xl.16594) | 1.3 | 3.5 | 1.3 | 3.2 |
| Xl.14584 (similar to gastrula-specific protein kinase) | 2.9 | 10.6 | 10.1 | |
*
Where multiple ID numbers are indicated, the first was from the microarray annotation and the second is the most up-to-date transcript association for that retired number.