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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Pediatr Blood Cancer. 2010 Feb;54(2):242–249. doi: 10.1002/pbc.22308

Table III.

Multivariate analysis of parental descriptive characteristics and neonatal birth characteristicsb

Total cases (n = 2240) Total leukemia (n = 805) ALL (n = 645) CNS (n = 377)
Adjusted OR* 95 % CI Adjusted OR* 95 % CI Adjusted OR* 95 % CI Adjusted OR* 95 % CI
SGA (vs. AGA) 0.93 0. 80–1.10 0.88 0.68–1.13 0.78 0.57–1.05 0.98 0.70–1.38
LGA (vs. AGA) 1.29 1.11–1.49 1.49 1.20–1.85 1.66 1.32–2.10 1.14 0.82–1.58
 P (trend test)† 0.0016 0.0005 <0.0001 0.5128
 LGA (<4000 g) 1.42 1.07–1.88 1.42 0.91–2.21 1.5 0.97–2.52 1.12 0.57–2.20
 LGA (>4000 g) 1.25 1.06–1.48 1.49 1.17–1.90 1.67 1.29–2.16 1.15 0.79–1.65
Sex (male) 1.24 1.13–1.37 1.31 1.12–1.52 1.25 1.06–1.47 1.31 1.06–1.61
Ethnicity (AA vs. W) 0.64 0.54–0.76 0.57 0.42–0.76 0.39 0.26–0.57 0.70 0.49–0.98
Ethnicity (H vs. W) 0.85 0.77–0.93 1.04 0.89–1.22 1.01 0.85–1.20 0.60 0.48–0.75
Maternal age (≥35 years) 1.17 1.00–1.37 1.31 1.03–1.67 1.18 0.89–1.55 N/A
Congenital malformationa 2.24 1.50–3.34
Birth year 0.99 0.97–1.01 0.94 0.91–0.96 0.92 0.90–0.95 0.98 0.94–1.01
Secondary analysis
Birth weight
 (≤ 2500 g)c 1.04 0.83–1.31 0.91 0.62–1.33 0.80 0.51–1.25 0.93 0.56–1.56
 (≥ 4000 g)c 1.19 1.03–1.38 1.36 1.10–1.69 1.50 1.18–1.89 1.14 0.83–1.56
 P (trend test)† 0.1777 0.0064 0.0007 0.3672
Gestational age
  (<37 weeks) 1.04 0.88–1.24 1.02 0.77–1.35 1.12 0.83–1.53 0.99 0.67–1.47
 (>41 weeks) 0.86 0.74–1.01 0.91 0.71–1.15 0.94 0.72–1.23 1.07 0.78–1.47

ALL, acute lymphoblastic leukemia; CNS, central nervous system tumors; OR, odds ratio point estimate; CI, confidence interval; SGA, small for gestational age; AGA, appropriate for gestational age; LGA, large for gestational age; AA, African-American; W, White; H, Hispanic;

a

Subjects with Down syndrome excluded;

b

All models contained the variable of initial matching, birth year, to control for residual confounding;

c

OR and 95% CI were generated for all variables shown within the chart except birth weight. Birth weight (continuous, then categorical) were substituted into the model for LGA and SGA to obtain their respective OR and 95% CI. Values for other variables varied less than 5%;

†

Trend test obtained from the logistic regression model with adjustment for remaining variables;

*

OR adjusted for all variables containing values within each column.