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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Biol Psychiatry. 2010 Jan 1;67(1):36–43. doi: 10.1016/j.biopsych.2009.07.032

Figure 1.

Figure 1

HDAC inhibition significantly facilitates non-confined extinction and attenuates reinstatement of cocaine-CPP. (A) Schematic representation of non-confined extinction procedure. (B) Cocaine-CPP expression indicated by mean ± S.E.M. of time in CS+ vs. CS−. NaBut treated animals (n=10) exhibited significantly facilitated extinction as compared to vehicle treated animals (n=14). (C) NaBut treated mice (n=7) exhibited significantly attenuated cocaine-primed reinstatement (time in CS+ during test) as compared to vehicle treated mice (n=8). Gray dashed line indicates times in CS+ during initial test. (D) Treatment (NaBut, n=7; Vehicle, n=8) did not affect exploration in test apparatus indicated by mean ± S.E.M. of distance traveled during reinstatement test. * P < 0.05, compared between groups.