Table I.
Sequences of the EC loops selected for modeling
| Loop | GPCR | TM stem | Loop sequence (length, sequential numbering) | TM stem |
|---|---|---|---|---|
| EC1 | bRh | 96 YTSL | HGYFVFGP (8, 100-107) | TGCN 111 |
| sRh | 94 ISCF | LKKWIFGF (8, 98-105) | AACK 109 | |
| β2AR | 92 AHIL | MKMWTFGN (8, 96-105) | FWCE 107 | |
| β1AR | 100 TLVV | RGTWLWGS (8, 104-111) | FLCE 115 | |
| A2AR | 65 TIST | GFCAAC (6, 69-74) | HGCL 78 | |
| EC2 | bRh | 169 APAL | VGWSRYIPEGMQCSCGIDYYTPHEETN (27, 173-199) | NESF 203 |
| sRh | 168 IGAI | FGWGAYTLEGVLCNCSFDYISRDST (25, 172-196) | TRSN 200 | |
| β2AR | 167 LPIQ | MHWYRATHQEAINCYANETCCDFFTNQ (27, 171-197) | AYAI 201 | |
| β1AR | 175 LPIM | MHWWRDEDPQALKCYQDPGCCDFVTNR (27, 179-205) | AYAI 209 | |
| A2AR | 138 TPML | GWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMN (34, 142-175) | YMVY 179 | |
| EC3 | bRh | 274 YIFT | HQGSDFGP (8, 278-285) | IFMT 289 |
| sRh | 281 ALLA | QFGPLEWVTP (10, 285-294) | YAAQ 298 | |
| β2AR | 294 IVHV | IQDNLIRKE (9, 298-306) | VYIL 310 | |
| β1AR | 311 IVNV | FNRDLVPDW (9, 315-323) | LFVF 327 | |
| A2AR | 254 CFTF | FCPDCSHAPLW (11, 258-268) | LMYL 272 |