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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Proteins. 2010 Feb 1;78(2):271–285. doi: 10.1002/prot.22537

Table V.

Modeling results for insertion of additional disulfide bridges in the EC loops

GPCR β2AR β1AR A2AR
Additional disulfide bridges C259- C259-
C184- C192- C259- C262; C262;
C190 C198 C262 C74- C74-
C146 C146;
C71-
C159

Low-energy conformers 260 285 46 27 12

Rms, Å EC1+EC2+EC3 3.4 4.0 4.6 4.7 4.1
EC1 1.4 2.1 1.7 1.8 1.9
EC2 3.7 4.1 5.7 5.5 4.8
EC3 1.9 2.3 1.8 1.6 1.6