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Schematic presentation of the radiotracer design. The targeting biomolecule is a multimeric cyclic RGD peptide. The PKM linker is used to modify radiotracer pharmacokinetics. For the metal-containing radiotracers, a multidentate BFC is often used to attach the metallic radionuclide to the targeting biomolecule. For 18F-based radiotracers, an organic precursor or synthon is often needed to attach 18F onto the multimeric cyclic RGD peptide.
