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Inhibition and acceleration of enzymes: (a) The effect of KET and QIN on the TGZ metabolism by Cyt P450 3A present in microsome-bioreactors. Data collected after 10 min. incubation in the presence of NADPH and QIN or KET. (b) CapLC chromatograms illustrating the metabolites formed with exposure of TGZ to HLM-bioreactors in the presence of NAPDH with and without KET.
