Table 2.

Patient Characteristics

	Arm
Characteristic	A	B	C	D	Total
Number of patients	38	40	38	53	167
Age, years
Median	62	61	61	58	61
Range	(26–83)	(44–84)	(35–78)	(37–83)	(26–84)
Sex, %
Male	58	75	74	66	69
Female	42	25	26	34	31
AJCC Stage, %
M1a	2	5	0	0	2
M1b	8	18	3	0	6
M1c	90	77	97	100	92
EECOG PS, %
PS 0	71	90	50	72	75
PS1	29	10	50*	28	25
No. prior therapies, median	0	0	1	0	0
Prior chemotherapy, %	11	10	100	19	37
LDH, %
<ULN	61	58	36	47	51
ULN < LDH <2XULN	23	23	42	36	31
>2XULN	16	19	22	17	18

^*p <0.05 compared to Arms A, B, D. Abbreviations: AJCC, American Joint Committee on Cancer; ECOG, Eastern Cooperative Group; PS Performance Status; ULN, Upper Limit of Normal