Table 4.
Response Rates
| Randomized | |||||
|---|---|---|---|---|---|
| Arms | A | B | A+B | C | D |
| Temozolomide dosing | Extended | Standard | Extended | Standard | |
| Brain Metastases | − | − | − | +/− | + |
| Proir Temozolomide | − | − | − | + | − |
| Overall Response Rate*,% | 24 | 15 | 19 | 0 | 15 |
| 95% Cl | [11–40] | [6–30] | [11–30] | − | [7–29] |
| Stable Disease Rate, % | 42 | 58 | 50 | 26 | 48 |
| 95% Cl | [29–59] | [41–73] | [39–62] | [14–44] | [33–62] |
| Progressive Disease Rate, % | 34 | 27 | 31 | 74 | 37 |
| Totel Evaluable(No.) | 38 | 40 | 78 | 38 | 52 |
*
Overall Response Rate: There was one complete response in Arm A. All other response were partial responses.