Table 1.
Demographic characteristics of schizophrenia patients as a function of dementia severity
| No dementia (N=16) |
Questionable dementia (N=14) |
Mild/moderate dementia (N = 26) |
Severe dementia (N=54) |
Between-group differences (post-hoc tests) |
|
|---|---|---|---|---|---|
| Demographic Variable | |||||
| Age at death (years) | 79.13 (7.12) | 68.36 (19.49) | 78.04 (7.17) | 82.80 (10.08) | ND=MM=S>QU** |
| N female (%) | 8 (50.0) | 9 (64.3) | 16 (61.5) | 21 (38.89) | n.s. |
| Education (years) | 10.16 (3.88) | 9.46 (3.12) | 10.58 (3.57) | 9.09 (3.30) | n.s. |
| Postmortem Interval (h) | 4.29 (3.04) | 4.63 (2.68) | 6.17 (5.07) | 6.47 (5.03) | n.s. |
| Time from last assessment (months) | 7.29 (2.84) | 6.78 (3.49) | 7.52 (3.48) | 8.23 (4.03) | n.s. |
| MMSE2 score | 19.29 (9.11) | 14.42 (10.81) | 14.50 (8.96) | 6.97 (8.74) | ND=QU=MM>S*** |
| CDR sum of boxes score | 0.43 (0.39) | 1.71 (0.82) | 4.10 (1.53) | 11.31 (5.30) | ND<QU<MM<S*** |
| PANSS general | 40.92 (14.05) | 40.20 (11.48) | 45.59 (9.48) | 47.59 (11.67) | n.s. |
| PANSS positive | 18.28 (10.10) | 18.90 (5.28) | 20.68 (7.31) | 16.96 (5.44) | ND=QU=MM>S* |
| PANSS negative | 22.00 (8.59) | 28.20 (9.34) | 28.14 (7.31) | 32.91 (9.98) | ND<QU=MM=S** |
| N ApoE4 carriers (%) | 0 (0.0) | 2 (6.7) | 12 (46.2) | 15 (27.8) | ND=QU<MM=S* |
Note: “ND” denotes no dementia, “mild/moderate” denotes CDR scores of 1 or 2, “severe” denotes CDR scores greater than 2. MMSE denotes Mini-Mental State Examination. PANSS denotes Positive and Negative Syndrome Scale. Standard deviations in parentheses. ND denotes no dementia, QU denotes questionable, MM mild to moderate, and S secre dementia. Results from post hoc t-test.
***
p < .001
**
p < .01
*
p < .05.