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PanIN lesions associated parenchymal abnormalities (hematoxylin-eosin, 40X) . A: A PanIN-1B lesion with associated lobular parenchyma showing partial acinar atrophy, acinar to ductal metaplasia. Note: residual normal acinar cells. B: A PanIN-3 lesion with associated parenchymal showing lobulocentric atrophy with loss of acinar parenchyma in a lobular pattern, fibrosis, and acinar-ductal metaplasia, and clusters of islet of Langerhans.
