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. 2009 Oct 21;35(2):570–580. doi: 10.1038/npp.2009.163

Figure 8.

Figure 8

Downregulation of zif268 in male rats, but not in female rats, abolishes sex differences in social interaction: (a) intact male and female rats treated zif268 missense or antisense oligodeoxynucleotide exhibit similar locomotor activity during the open field test. (b) intact male and female rats treated zif268 missense or antisense oligodeoxynucleotide spend similar time in the center of the open field. (c) intact male rats treated with zif268 missense-oligodeoxynucleotide (MALE zif MS, n=8) show greater social interaction than female rats treated with the same construct (FEMALE zif MS, n=10). This sex difference in social interaction is abolished when male rats are treated with zif268 antisense (MALE zif AS, n=9). Female rats treated with zif268 MSO or zif268 AS (FEMALE zif AS, n=7) do not differ in their social interaction time. *Significant difference when compared with MALE zif MS. (d) extent of diffusion of biotinylated-zif268-MSO within the mPFC. The diffusion covered the cingulate cortex 1 and prelimbic mPFC. *p<0.05.