Table 4.

Host source proteins encoding HLA-A*0201 unique and increased peptides with direct interaction with the influenza A virus following infection.

Source Protein	Peptide Sequence	Function	Influenza Interaction
		Cytoskeleton Component	Influenza virus NP binds the actin cytoskeleton to promote cytoplasmic retention of vRNPs
Actin	FAGDDAPRA	Cell Structure, Integrity, and Mobility	Integrity of cytoskeleton is necessary for virus internalization into epithelial cells
			Maintains organization of lipid rafts during virus budding
	IINEPTAAA	Correct folding of nascent polypeptides	Colocalizes with nuclear M1 to promote nuclear export of vRNPs
HSP70
	LLDVTPLSL	Disassembly of clathrin-coated vesicles	Inhibits nuclear export of vRNPs at 41°C
	ILDKKVEKV	Correct folding of nascent polypeptides	Nuclear import of influenza polymerase proteins
HSP90
	ALLSSGFSL	Refolding denatured proteins	Assembly of influenza polymerase complex
		Transportation of ribosomes and ribosomal proteins between nucleus and cytoplasm
Nucleolin	TLQEVFEKATF		Influenza virus NS1 localizes with nucleolin in host cell nucleoli
		During Cell Stress: Inhibits DNA replication, Stimulates DNA repair, and Down regulates c-myb
		Calcium dependent phospholipid binding protein	Incorporated into influenza virions
Annexin A2	SVIDYELIDQDA	Regulates cell growth
			Converts plasminogen into plasmin. Plasmin can cleave HA into HA1 and HA2
		Involved in signal transduction pathways