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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Glia. 2010 Feb;58(3):300–314. doi: 10.1002/glia.20924

Fig. 7.

Fig. 7

The huS100B transgene increases Iba1 positive reactive microglia in Tg2576 mice. Data were obtained from Tg2576 [n = 10 (5 males and 5 females) at 9 months of age; n = 14 each (7 males and 7 females) at 13, 15, and 19 months of age] and Tg2576-huS100B mice [n = 12 (6 males and 6 females) at 9 months of age; n = 16 each (8 males and 8 females) at 13, 15, and 19 months of age]. (A) Representative photomicrographs of Iba1 immunohistochemistry for β-amyloid plaque-associated microgliosis are shown in Tg2576 and Tg2576-huS100B mice at 19 months of age in each brain region indicated on the left. Scale bar denotes 50 μm. (B) Quantitative image analysis for Iba1 burden is shown in cingulate cortex (CC, top), hippocampus (H, middle), and entorhinal cortex (EC, bottom). All statistical comparisons are within brain region and between Tg2576 and Tg2576-huS100B mice at 9, 13, 15, and 19 months of age. *** P < 0.001 vs. Tg2576 mice.