Table 1. Pretreatment Characteristics.
| Dose Level I (68.4Gy @ 1.8Gy/Fraction) |
Dose Level II (73.8Gy @ 1.8Gy/Fraction) |
Dose Level III (79.2Gy @ 1.8Gy/Fraction) |
Dose Level IV (74Gy @ 2.0Gy/Fraction) |
Dose Level V (78Gy @ 2.0Gy/Fraction) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group 1 (n=75) |
Group 2 (n=33) |
Group 3 (n=4) |
Group 1 (n=97) |
Group 2 (n=108) |
Group 3 (n=95) |
Group 1 (n=104) |
Group 2 (n=63) |
Group 1 (n=115) |
Group 2 (n=141) |
Group 1 (n=119) |
Group 2 (n=101) |
||
| Age | < 70 | 53% | 39% | 100% | 43% | 48% | 54% | 67% | 56% | 51% | 43% | 54% | 48% |
| ≥ 70 | 47% | 61% | 0% | 57% | 52% | 46% | 33% | 44% | 49% | 57% | 46% | 52% | |
| T-Stage | T1 | 56% | 27% | 0% | 67% | 29% | 0% | 54% | 27% | 65% | 40% | 68% | 46% |
| T2 | 44% | 73% | 0% | 33% | 71% | 0% | 46% | 73% | 35% | 60% | 32% | 54% | |
| T3 | 0% | 0% | 100% | 0% | 0% | 100% | 0% | 0% | 0% | 0% | 0% | 0% | |
| Institutional Gleason | 2-6 | 93% | 36% | 50% | 95% | 41% | 28% | 94% | 22% | 91% | 21% | 87% | 12% |
| 7 | 7% | 36% | 25% | 5% | 41% | 44% | 6% | 46% | 9% | 56% | 13% | 71% | |
| 8-10 | 0% | 27% | 25% | 0% | 19% | 27% | 0% | 32% | 0% | 23% | 0% | 17% | |
| Initial PSA | ≤ 10 | 75% | 42% | 0% | 81% | 43% | 35% | 87% | 43% | 86% | 50% | 77% | 43% |
| 11-20 | 24% | 33% | 25% | 19% | 35% | 37% | 13% | 38% | 14% | 32% | 23% | 41% | |
| ≥ 20 | 1% | 24% | 75% | 0% | 22% | 28% | 1% | 19% | 0% | 18% | 0% | 17% | |
| Induction Hormones | Yes | 8% | 15% | 50% | 20% | 48% | 87% | 30% | 68% | 22% | 52% | 8% | 34% |
| Mean ICRU reference dose | Gy ± (sd) | 71.1 ± 1.5 | 71.3 ± 1.3 | 71.2 ± 1.3 | 76.7 ± 1.6 | 77.3 ± 1.5 | 77.4 ± 1.2 | 81.2 ± 1.6 | 82.3 ± 1.4 | 77.1 ± 1.3 | 77.0 ± 1.2 | 81.6 ± 1.1 | 81.2 ± 1.2 |
| Median Follow-up All Patients | Years (range) |
9.4 (1.5,12.4) |
9.6 (0.1,12.3) |
10.3 (6.4,12.1) |
9.9 (1.3,11.7) |
8.5 (0.9,12.0) |
7.4 (0.2,11.6) |
8.5 (1.1,10.5) |
9.2 (3.5,10.6) |
7.7 (1.0,8.7) |
7.0 (0.9,8.5) |
5.9 (0.1,7.3) |
6.1 (0.5,7.1) |
| Median Follow-up Surviving Patients | Years (range) |
10.0 (3.0,12.4) |
11.1 (3.7,12.3) |
12.1 (12.1,12.1) |
10.2 (3.1,11.7) |
10.1 (0.9,12.0) |
7.8 (0.3,11.6) |
8.9 (2.1,10.5) |
9.3 (4.9,10.6) |
7.8 (1.0,8.7) |
7.2 (2.8,8.5) |
6.1 (1.3,7.3) |
6.2 (2.1,7.1) |