Table 2. Univariate Cox Proportional Hazard Model-Time to Late GI/GU Grade 2+ Toxicity in Disease Group.
| Comparison | HR* (95% C.I.) |
|||
|---|---|---|---|---|
| Disease Group | RL | p-value** | ||
| Group 1 | Dose Level I | Dose Level II | 0.84 (0.48, 1.47) |
0.5459 |
| Dose Level III | 0.77 (0.43, 1.35) |
0.3544 | ||
| Dose Level IV | 1.33 (0.79, 2.22) |
0.2826 | ||
| Dose Level V | 1.93 (1.17, 3.18) |
0.0101† | ||
| Dose Level II | Dose Level III | 0.91 (0.52, 1.58) |
0.7346 | |
| Dose Level IV | 1.58 (0.96, 2.59) |
0.0723 | ||
| Dose Level V | 2.29 (1.42, 3.71) |
0.0007†† | ||
| Dose Level III | Dose Level IV | 1.74 (1.05, 2.86) |
0.0306 | |
| Dose Level V | 2.52 (1.56, 4.10) |
0.0002††† | ||
| Dose Level IV | Dose Level V | 1.46 (0.96, 2.20) |
0.0761 | |
| Group 2 | Dose Level I | Dose Level II | 0.78 (0.36, 1.69) |
0.5323 |
| Dose Level III | 0.92 (0.41, 2.05) |
0.8408 | ||
| Dose Level IV | 1.28 (0.62, 2.62) |
0.5051 | ||
| Dose Level V | 2.04 (0.99, 4.20) |
0.0526 | ||
| Dose Level II | Dose Level III | 1.18 (0.64, 2.18) |
0.6033 | |
| Dose Level IV | 1.63 (0.98, 2.72) |
0.0591 | ||
| Dose Level V | 2.61 (1.56, 4.35) |
0.0002†† | ||
| Dose Level III | Dose Level IV | 1.39 (0.80, 2.41) |
0.2474 | |
| Dose Level V | 2.22 (1.27, 3.87) |
0.0051††† | ||
| Dose Level IV | Dose Level V | 1.60 (1.05, 2.43) |
0.0276†††† | |
*
Hazard ratio: A hazard ratio quantifies how much more (less) risk patients at some level have than those at the reference level (RL). A confidence interval that includes 1 indicates that no difference exists between the subgroups.
**
p-value from Chi-square test using the Cox proportional hazards model
†
It is statistically significant at the significance level of 0.05/4=0.012
††
It is statistically significant at the significance level of 0.05/3=0.016
†††
It is statistically significant at the significance level of 0.05/2=0.025
††††
It is statistically significant at the significance level of 0.05